Evren Algın-Yapar 
For correspondence:- Email: evren.yapar@yahoo.com Tel:+905323825686
Received: 18 December 2013 Accepted: 19 February 2014 Published: 24 March 2014
Citation: Algın-Yapar E. Nasal Inserts for Drug Delivery: An Overview. Trop J Pharm Res 2014; 13(3):459-467 doi: 10.4314/tjpr.v13i3.22
© 2014 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..
Nasal mucosa, owing to its high vascularity and thin epithelial membrane, has been widely explored for drug administration in the last two decades. Within that period various nasal dosage forms have been researched and developed. Among them, nasal inserts are easily prepared by lyophilization or gelsification, allow easy dosing with a high potential for systemic administration, enable avoidance of hepatic first pass metabolism, and make possible the release of active ingredient in a controlled manner. In this review, the benefits, limitations and absorption mechanisms of the nasal route, as well as findings from nasal insert-related studies are addressed.
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